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Learn more about this top honor. The pain is often severe and may last for a few minutes or for several hours after defaecation. There may be more than one pathogenic process leading to the development of chronic fissures: GTN is metabolized at a cellular level to release nitric oxide which in turn mediates relaxation of the internal sphincter via the guanylate cyclase pathway. Clear Turn Off Turn On. In the past it was believed that the passage of a hard stool traumatized the anal mucosa.
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Anal Fissure: A Common Cause of Anal Pain


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Anal Fissure: A Common Cause of Anal Pain


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My experience with a chronic anal fissure

This softens stools and makes them easier to pass - less pain and less damage to existing fissures. The anus, increasing the blood supply to the fissure and helping it heal faster. Advertising revenue supports our not-for-profit mission. She notices some intermittent bleeding with defecation.
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